Fri Jun 09 2023

37 articles - From Friday Jun 02 2023 to Friday Jun 09 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Best (but oft forgotten) practices: Efficient sample sizes for commonly used trial designs.

How to calculate sample sizes for maximin designs is illustrated for examples from nutrition. Several computer programs that are helpful in calculating sample sizes for optimal and maximin designs are discussed as well as some results on optimal designs for other types of outcomes.

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Body composition reference charts for infants from birth to 24 months: Multicenter Infant Body Composition Reference Study.

These reference charts will strengthen the interpretation and understanding of body composition in infants across the first 24 mo of life.

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Estimating habitual iodine intake and prevalence of inadequacy from spot urine in cross-sectional studies: a modeling analysis to determine the required sample size.

The sample size for cross-sectional studies aiming to assess the prevalence of inadequate iodine intake depend on the expected prevalence, the overall variance in intake, and the study design. However, an N of 400 participants with a repeated measure of 25% may be used as guidance when planning observational studies applying simple random sampling.

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Hemoglobin distributions and prevalence of anemia in a multiethnic United States pregnant population.

Anemia was evident in more than one-quarter of a multiethnic United States pregnant population despite current universal prenatal iron supplementation recommendations. Prevalence of anemia was higher among Black women and lowest among Asian and White women.

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Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study.

Frequent nut consumption was associated with smaller decline in general cognitive performance over a 2-year period in older adults at risk of cognitive decline. Randomized clinical trials to verify our findings are warranted.

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Impact of a low-carbohydrate versus low-fat breakfast on blood glucose control in type 2 diabetes: a randomized trial.

Advice and guidance to consume a LC breakfast appears to be a simple dietary strategy to reduce overall energy and carbohydrate intake and improve several CGM variables when compared to a CTL breakfast in persons living with T2D.

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Long-term treatment with teduglutide: a 48-week open-label single-center clinical trial in children with short bowel syndrome.

Increased intestinal absorption and PN dependency reduction were observed with teduglutide treatment in children with SBS-IF.

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Moderate Consumption of Freeze-dried Blueberry Powder Increased Net Bone Calcium Retention Compared with No Treatment in Healthy Postmenopausal Women: A Randomized Crossover Trial1,2.

Moderate consumption (<1 cup/day) of blueberries may be an effective strategy to attenuate bone loss in healthy postmenopausal women. Clinical trial registration

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Pre- and postnatal small quantity lipid-based nutrient supplements and children's social-emotional difficulties at age 9-11 years in Ghana: Follow-up of a randomized controlled trial.

Overall positive effects of SQ-LNS on social-emotional development previously found at age 5 y were not sustained to age 9-11 y, however there was some evidence of positive effects among children in less enriched environments. The lack of effects may be due to low prevalence of social-emotional problems at pre-adolescence, resulting in little potential to benefit from early nutritional intervention at this age in this outcome domain. Follow-up during adolescence, when social-emotional problems more typically onset, should yield further insights. REGISTRY clinicaltrials.gov NCT00970866 REGISTRY AND REGISTRY NUMBER Registered at clinicaltrials.gov as NCT00970866.

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Total energy expenditure assessed by 24-hour whole-room indirect calorimeter in patients with colorectal cancer: baseline findings from the PRIMe study.

This is the largest study to assess TEE of patients with cancer by whole-room indirect calorimeter and highlights the need for improved determination of energy requirements in this population. Energy requirements predicted using 30 kcal/kg overestimated TEE by 1.44 times in a controlled sedentary environment and TEE was outside of the predicted requirement range for most. Special considerations are warranted when determining TEE of patients with colorectal cancer, including BMI, body composition and tumor location. This is a baseline cross-sectional analysis from a clinical trial (ClinicalTrials.gov Identifier NCT02788955) available at

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Unexpected upper gastrointestinal polyps in patients with short bowel syndrome treated with teduglutide: need for close monitoring.

Our study highlights the importance of performing follow-up upper and lower gastrointestinal endoscopy in SBS patients treated with teduglutide and the potential need to make changes to the recommendations with respect to treatment initiation and follow-up.

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Inflamm Bowel Dis

A Novel 8-Predictors Signature to Predict Complicated Disease Course in Pediatric-onset Crohn's Disease: A Population-based Study.

A combination of clinical, serotypic, and genotypic variables can predict disease progression in this population-based pediatric-onset CD cohort. Independent validation is needed before it can be used in clinical practice.

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A Phase I Study of Ex Vivo Expanded Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for the Treatment of Pediatric Perianal Fistulizing Crohn's Disease.

Bone marrow-derived mesenchymal stem cells offer a safe, and likely effective, treatment approach for pediatric perianal fistulizing Crohn's disease.

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Characteristics, Clinical Outcomes, and Prognosis of Anal and Pouch-related Carcinoma in Patients With Crohn's Disease.

Anal and pouch-related carcinomas were rare complications of CD, and long-standing perianal diseases were an important risk factor. Anal EUA improved the diagnostic yield. Newer cancer treatment strategies and surgery were associated with excellent survival outcome.

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Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for Monitoring of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations in Patients With Inflammatory Bowel Disease.

This study clinically validated a finger prick-based capillary blood self-sampling technique allowing concomitant home monitoring of biological levels and CRP for patients with IBD, who reported substantial support, tolerability, and practicality.

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Creeping Fat in the Pathogenesis of Crohn's Disease: An Orchestrator or a Silent Bystander?

Interestingly, there is growing evidence for an alternative immunomodulatory function of creeping fat as a second barrier that prevents an abnormal systemic inflammatory response at the expense of an increasingly proliferating profibrotic environment. Further studies are needed to clarify how this modified adipose tissue exerts its antithetic effect during the course of Crohn's disease.

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Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis.

NRG4 regulates colonic epithelial ST3GAL4 and thus may allow for robust recruitment of CD8+ T cells during adaptive immune responses in colitis. On the other hand, NRG4 loss exacerbates injury driven by innate immune responses.

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Gut Microbiota Signatures Are Associated With Psychopathological Profiles in Patients With Ulcerative Colitis: Results From an Italian Tertiary IBD Center.

Our study confirmed the presence of high levels of psycho-emotional distress in UC patients, alongside alterations of the intestinal microbiota, and highlighted some families and genera of bacteria (Enterobacteriaceae, Streptococcus, Veillonella, Klebsiella, and Clostridiaceae) as potential markers of an altered gut-brain axis in these patients.

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Impact of Inflammatory Bowel Disease on Patients' Caregivers: Results From a French Survey.

IBD has a high impact on different aspects of life of patients' caregivers. Therefore, interventions to reduce the disease burden in this population are needed.

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Inflammatory Bowel Disease in Appalachian Kentucky: An Investigation of Outcomes and Health Care Utilization.

There is disproportionately higher IBD health care utilization in Appalachian Kentucky compared with al cohorts, including the national rural population. There is a need for aggressive investigation into root causes of these disparate outcomes and identification of barriers to appropriate IBD care.

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One-Year Clinical Outcomes of Subcutaneous Infliximab Maintenance Therapy Compared With Intravenous Infliximab Maintenance Therapy in Patients With Inflammatory Bowel Disease: A Prospective Cohort Study.

The SC IFX switch induced a higher 1-year durable remission rate than continuing IV IFX in patients with IBD during scheduled maintenance therapy, showing similar safety.

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Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.

These analyses identified novel IBD loci, in addition to characterizing sex-specific patterns of associations underlying sex-dimorphic associations. By elucidating the role of sex in IBD genetics, our study will help enhance our understanding of the differences between the sexes in IBD biology and underscores a need to move beyond conventional sex-combined analyses to appreciate the genetic architecture of IBD more comprehensively.

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J Crohns Colitis

Autoimmune pancreatitis in patients with inflammatory bowel disease - a real-world multicentre collaborative ECCO CONFER study.

In this large international cohort of patients with concomitant AIP-IBD, most patients have type 2 AIP and colonic IBD. AIP course is relatively benign and long-term outcomes are favourable, however, one-quarter develop pancreatic complications. Age, familial history of IBD and CD may predict uncomplicated AIP course.

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Fatigue in patients with newly diagnosed inflammatory bowel disease: Results from a prospective inception cohort, the IBSEN III study.

SF affects approximately two-thirds of patients newly diagnosed with IBD. Fatigue was associated with depressive symptoms, sleep disturbances, and increased pain intensity in both diagnoses, while clinical and endoscopic activity were associated factors only in UC.

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Hypomethylation and overexpression of Th17-associated genes is a hallmark of intestinal CD4+ lymphocytes in Crohn's disease.

The methylome of CD patients demonstrate an overall dominant hypermethylation yet hypomethylation is more concentrated in proinflammatory pathways, including Th17 differentiation. Hypomethylation of Th17-related genes associated with areas of open chromatin and CTCF binding sites constitutes a hallmark of CD-associated intestinal CD4 + cells.

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Influence of Early Life Factors, including Breastmilk Composition, on the Microbiome of Infants Born to Mothers with and without Inflammatory Bowel Disease.

Maternal IBD diagnosis influences microbiota in their offspring during early life. The proteomic profile of breastmilk of women with IBD differs from that of women without IBD, with distinct time-dependent associations with baby's gut microbiome and fecal calprotectin.

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Pancreatology

A comparative study between computed tomography and endoscopic ultrasound in the detection of a mural nodule in intraductal papillary mucinous neoplasm -Multicenter observational study in Japan.

EUS was superior to CT for the detection of MN in IPMN. EUS surveillance is essential for the detection of MNs.

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Defined, low threshold for caesarean section and multidisciplinary team management improves fetal outcome from acute pancreatitis in pregnancy.

Multidisciplinary collaboration and a defined, low threshold for C-section improve fetal outcomes in patients with APIP.

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Goal-directed fluid management associates with fewer postoperative fluid collections in pancreatoduodenectomy patients.

Optimization of intraoperative fluid management through target-controlled strategies and early diuresis were associated with a lower frequency of fluid collections in postoperative CT.

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Identification of protease-sensitive but not misfolding PNLIP variants in familial and hereditary pancreatitis.

I265R, were found to segregate with the disease in three families, including one exhibiting a classical autosomal dominant inheritance pattern. Consistent with previous findings, protease-sensitive variant-positive patients were often characterized by early-onset disease and invariably experienced recurrent acute pancreatitis, although none has so far developed chronic pancreatitis.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Seize the whey! Whey preloads for control of postprandial glycemia in metabolic disease.

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Teduglutide for the treatment of short bowel syndrome: a double-edged sword?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Multiple Orocutaneous Extraintestinal Manifestations in Ulcerative Colitis Patient: Complete Response to Ustekinumab.

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Use of Immune Checkpoint Inhibitors in Patients With Inflammatory Bowel Disease After Ileal Pouch-Anal Anastomosis.

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Liver Transpl

Liver transplant policy corner MELD 3.0.

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Outcomes for salvage abdominal stereotactic body radiation therapy for hepatocellular carcinoma after liver transplantation.

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Technical advances in living donor liver transplantation: maintaining a view of both donor and recipient outcomes.

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Letters&Replies

Letters to the editors and authors’ replies